A Universal Tumor-Specific Promoter for Cancer Gene Therapy
| Autor: | O. B. Filyukova, V. V. Pleshkan, E. V. Snezhkov, Eugene D. Sverdlov, A. V. Sass, I. V. Alekseenko |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Survivin Biophysics Tumor specific Cytomegalovirus Biology Biochemistry Inhibitor of Apoptosis Proteins 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Neoplasms Humans Telomerase reverse transcriptase Promoter Regions Genetic Promoter Genetic Therapy General Chemistry General Medicine In vitro 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Cancer research Cancer gene Ex vivo |
| Zdroj: | Doklady Biochemistry and Biophysics. 480:158-161 |
| ISSN: | 1608-3091 1607-6729 |
| DOI: | 10.1134/s1607672918030092 |
| Popis: | An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters was constructed. Studies in in vitro and ex vivo therapeutic systems showed that the designed promoter exhibits a high activity in tumor cells, which is comparable to the activity of the CMV constitutive promoter. |
| Databáze: | OpenAIRE |
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