Synthesis, characterization and biological approach of metal chelates of some first row transition metal ions with halogenated bidentate coumarin Schiff bases containing N and O donor atoms
| Autor: | Sangamesh A. Patil, Chetan T. Prabhakara, Shivashankar M. Kinnal, Prema S. Badami, Shivakumar S. Toragalmath |
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| Rok vydání: | 2015 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Denticity Antifungal Agents Spectrophotometry Infrared Stereochemistry Nitrogen Proton Magnetic Resonance Spectroscopy Biophysics Molar conductivity 010402 general chemistry 01 natural sciences Metal chemistry.chemical_compound Halogens Transition metal Coumarins Polymer chemistry Transition Elements Moiety Molecule Radiology Nuclear Medicine and imaging Chelation Schiff Bases Chelating Agents Radiation Schiff base Radiological and Ultrasound Technology 010405 organic chemistry 0104 chemical sciences Anti-Bacterial Agents Oxygen chemistry visual_art visual_art.visual_art_medium |
| Zdroj: | Journal of photochemistry and photobiology. B, Biology. 157 |
| ISSN: | 1873-2682 |
| Popis: | The impregnation of halogen atoms in a molecule is an emerging trend in pharmaceutical chemistry. The presence of halogens (Cl, Br, I and F) increases the lipophilic nature of molecule and improves the penetration of lipid membrane. The presence of electronegative halogen atoms increases the bio- activity of core moiety. In the present study, Co(II), Ni(II) and Cu(II) complexes are synthesised using Schiff bases (HL(I) and HL(II)), derived from 8-formyl-7-hydroxy-4-methylcoumarin/3-chloro-8-formyl-7-hydroxy-4-methylcoumarin with 2,4-difluoroaniline/o-toluidine respectively. The synthesized compounds were characterized by spectral (IR, NMR, UV-visible, Mass, ESI-MS, ESR), thermal, fluorescence and molar conductivity studies. All the synthesized metal complexes are completely soluble in DMF and DMSO. The non-electrolytic nature of the metal complexes was confirmed by molar conductance studies. Elemental analysis study suggest [ML2(H2O)2] stoichiometry, here M=Co(II), Ni(II) and Cu(II), L=deprotonated ligand. The obtained IR data supports the binding of metal ion to Schiff base. Thermal study suggests the presence of coordinated water molecules. Electronic spectral results reveal six coordinated geometry for the synthesized metal complexes. The Schiff bases and their metal complexes were evaluated for antibacterial (Pseudomonas aureginosa and Proteus mirabilis), antifungal (Aspergillus niger and Rhizopus oryzae), anthelmintic (Pheretima posthuma) and DNA cleavage (Calf Thymus DNA) activities. |
| Databáze: | OpenAIRE |
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