Metabolomic identification of novel diagnostic biomarkers in ectopic pregnancy

Autor:	Ceren Katar, Salim Erkaya, Ray O. Bahado-Singh, Ismail Mert, Ayse Citil, Onur Turkoglu, Stewart F. Graham, Ali Yilmaz, Dilek Uygur, Praveen Kumar
Rok vydání:	2019
Předmět:	Adult medicine.medical_specialty Turkey Endocrinology Diabetes and Metabolism Metabolite Proton Magnetic Resonance Spectroscopy Clinical Biochemistry Logistic regression 01 natural sciences Biochemistry Gastroenterology 03 medical and health sciences chemistry.chemical_compound Metabolomics Pregnancy Internal medicine medicine Humans Prospective Studies 030304 developmental biology 0303 health sciences Ectopic pregnancy Receiver operating characteristic business.industry 010401 analytical chemistry medicine.disease Molecular medicine Confidence interval 0104 chemical sciences Pregnancy Ectopic chemistry Case-Control Studies Biomarker (medicine) Female business Biomarkers
Zdroj:	Metabolomics : Official journal of the Metabolomic Society. 15(11)
ISSN:	1573-3890
Popis:	Ectopic pregnancy (EP) is a potentially life-threatening condition and early diagnosis still remains a challenge, causing a delay in management leading to tubal rupture. To identify putative plasma biomarkers for the detection of tubal EP and elucidate altered biochemical pathways in EP compared to intrauterine pregnancies. This case–control study included prospective recruitment of 39 tubal EP cases and 89 early intrauterine pregnancy controls. Plasma samples were biochemically profiled using proton nuclear magnetic resonance spectroscopy (1H NMR). To avoid over-fitting, datasets were randomly divided into a discovery group (26 cases vs 60 controls) and a test group (13 cases and 29 controls). Logistic regression models were developed in the discovery group and validated in the independent test group. Area under the receiver operating characteristics curve (AUC), 95% confidence interval (CI), sensitivity, and specificity values were calculated. In total 13 of 43 (30.3%) metabolite concentrations were significantly altered in EP plasma (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9add97abb15919d39d00916c85d149d6 https://pubmed.ncbi.nlm.nih.gov/31630278 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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