Glycation of albumin with aging and diabetes in rats: changes in its renal handling
| Autor: | Jean Schaeverbeke, Hilaire Bakala, Philippe Verbeke, Martine Perichon, Bruno Corman |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty Glycosylation Diabetes Mellitus Experimental Excretion Glycation Albumins Internal medicine Diabetes mellitus medicine Albuminuria Animals Rats Wistar Analysis of Variance Proteinuria business.industry Albumin medicine.disease Streptozotocin Rats Endocrinology Postprandial Electrophoresis Polyacrylamide Gel Microalbuminuria medicine.symptom business Developmental Biology medicine.drug |
| Zdroj: | Mechanisms of Ageing and Development. 78:63-71 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(94)01527-s |
| Popis: | Albumin glycation was investigated in old rats to elucidate the link between the preferential excretion of glycated albumin and age-related microalbuminuria. Postprandial blood glucose and the glycated albumin in the serum and urine of 3-, 10- and 30-month-old Wistar rats and in streptozotocin diabetic rats were determined. Blood glucose increased from 1.46 +/- 0.046 g l-1 in 3-month-old rats to 2.08 +/- 0.06 (10 months) and 1.75 +/- 0.23 (30 months) (P0.05). Albumin glycation level in the serum increased from 0.79 +/- 0.07 nmol HCHO/nmol albumin (3 months) to 1.41 +/- 0.14 (10 months) and 1.73 +/- 0.21 (30 months) (P0.05); urinary level increased from 1.63 +/- 0.39 nmol HCHO/nmol albumin (3 months) to 2.92 +/- 0.57 (10 months) and 2.39 +/- 0.36 (30 months) (P0.01). The percent glycated albumin in serum rose from 3.33 +/- 0.64 to 6.81 +/- 0.63 and 6.99 +/- 1.79% of total albumin (P0.05), whereas the urine percentage decreased from 12.81 +/- 3.97 to 12.64 +/- 2.87 and 2.63 +/- 0.97% (P0.05) in 3-, 10- and 30-month-old rats, respectively. Editing decreased with aging from 4.28 +/- 0.83 (3 months) to 1.84 +/- 0.32 (10 months) and 0.52 +/- 0.14 (30 months) (P0.01). Editing in microproteinuric diabetic rats was lower (0.95 +/- 0.08) than in 3-month-old control rats (P0.01).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|