Vitamin D status in cats with cardiomyopathy
| Autor: | Min Zhang, John E. Rush, Jessica L. Ward, Wendy A. Ware, Andrew J. Makowski, Lisa M. Freeman |
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| Rok vydání: | 2020 |
| Předmět: |
Male
myocardial disease medicine.medical_specialty Heart disease 040301 veterinary sciences Cardiology Cardiomyopathy Standard Article 030204 cardiovascular system & hematology Cat Diseases 3‐epimer Gastroenterology 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Disease severity Internal medicine Left atrial enlargement medicine Vitamin D and neurology Animals Heart Atria Vitamin D feline lcsh:Veterinary medicine CATS 25(OH)D General Veterinary business.industry Age Factors 04 agricultural and veterinary sciences Fractional shortening medicine.disease Survival Analysis Standard Articles Diet Cross-Sectional Studies Echocardiography Cats lcsh:SF600-1100 Female SMALL ANIMAL Cardiomyopathies business Diet history |
| Zdroj: | Journal of Veterinary Internal Medicine, Vol 34, Iss 4, Pp 1389-1398 (2020) Journal of Veterinary Internal Medicine |
| ISSN: | 1939-1676 0891-6640 |
| DOI: | 10.1111/jvim.15833 |
| Popis: | Background Low vitamin D concentrations have been associated with advanced heart disease and poorer outcomes in people and dogs. Vitamin D status typically is assessed by serum 25(OH)D concentration. However, cats also produce notable amounts of a C-3 epimer of 25(OH)D (3-epi). Hypothesis/objectives Determine if vitamin D status, estimated by 25(OH)D3 alone or combined with 3-epi (summation vitD), is lower in cats with cardiomyopathy (CM) compared to clinically normal (N) cats and if indicators of disease severity are associated with vitamin D status. Animals Privately owned cats, 44 with CM and 56 N. Methods Cross-sectional observational study using clinical and echocardiographic findings, diet history, and serum 25(OH)D3 and 3-epi measurements. Results Cat age was negatively related to vitamin D status. Summation vitD was lower in CM cats (median = 47.1 ng/mL) compared to N cats (median = 58.65 ng/mL) both before (P = .03) and after (P = .04) accounting for age. However, 25(OH)D3 became nonsignificant between CM and N cats after age was included. Summation vitD was related positively to survival time and fractional shortening (FS), but negatively to left atrial enlargement (LAE) severity, both before and after accounting for age. For 25(OH)D3 alone, only survival time and FS remained significant after including age. Conclusions and clinical importance We report 25(OH)D3 and 3-epi concentrations in CM and N cats. Age had an important (negative) relationship to vitamin D status. After accounting for age, summation vitD was lower in CM cats. Vitamin D status was related positively to survival time and FS, but negatively to LAE severity. |
| Databáze: | OpenAIRE |
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