Interleukin-4 receptor-targeted liposomal doxorubicin as a model for enhancing cellular uptake and antitumor efficacy in murine colorectal cancer
| Autor: | Hong-Wen Liu, Chin-Yau Chen, Maggie Lu, Wei-Nan Lian, Chih-Yung Yang, Jeng-Kai Jiang, Chi Hung Lin, Ya-Ching Tsai, Ming-Cheng Wei, Ju-Yu Tseng, Ruey-Hwa Lu, Shu-Ching Liang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research Colorectal cancer Apoptosis Pharmacology Mice Interleukin-4 receptor Cell Line Tumor medicine Animals Humans Doxorubicin Receptor Liposome Cardiotoxicity Mice Inbred BALB C Antibiotics Antineoplastic integumentary system Chemistry fungi medicine.disease Research Papers Receptors Interleukin-4 Tumor Burden Treatment Outcome Oncology Targeted drug delivery Liposomes Molecular Medicine Drug Screening Assays Antitumor Colorectal Neoplasms Peptides Neoplasm Transplantation medicine.drug |
| Zdroj: | Cancer biologytherapy. 16(11) |
| ISSN: | 1555-8576 |
| Popis: | Our previous studies showed that colorectal tumor has high interleukin-4 receptor α (IL-4Rα) expression, whereas adjacent normal tissue has low or no IL-4Rα expression. We also observed that human atherosclerotic plaque-specific peptide-1 (AP1) can specifically target to IL-4Rα. In this study, we investigated the therapeutic efficacy and systemic toxicity of AP1-conjuagted liposomal doxorubicin. AP1 bound more strongly to and was more efficiently internalized into IL-4Rα-overexpressing CT26 cells than CT26 control cells. Selective cytotoxicity experiment revealed that AP1-conjugated liposomal doxorubicin preferentially killed IL-4Rα-overexpressing CT26 cells. AP1-conjugated liposomal doxorubicin administered intravenously into mice produced significant inhibition of tumor growth and showed decreased cardiotoxicity of doxorubicin. These results indicated that AP1-conjugated liposomal doxorubicin has a potent and selective anticancer potential against IL-4Rα-overexpressing colorectal cancer cells, thus providing a model for targeted anticancer therapy. |
| Databáze: | OpenAIRE |
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