Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma
| Autor: | Fangyuan Li, Zhang Sumei, Anqi Wang, Dan Guo, Bo Long, Xiaoxiao Zhao, Binglu Li, Jian Sun, Dingyan Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Proto-Oncogene Proteins B-raf Cancer Research Biology Thyroid carcinoma 03 medical and health sciences Young Adult 0302 clinical medicine Circular RNA microRNA medicine Humans Thyroid Neoplasms Thyroid cancer Aged Neoplasm Staging Oncogene Sequence Analysis RNA Gene Expression Profiling RNA Cancer High-Throughput Nucleotide Sequencing General Medicine Articles RNA Circular Middle Aged medicine.disease Molecular medicine 030104 developmental biology Oncology Thyroid Cancer Papillary 030220 oncology & carcinogenesis Lymphatic Metastasis Mutation Cancer research Disease Progression Female |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Circular RNAs (circRNAs) are a novel class of RNAs, with higher stability and tissue specificity, which may be of value as novel clinical markers. High‑throughput RNA sequencing was used to profile the expression of circRNAs in 5 pairs of cancer and normal tissues, and reverse transcription‑quantitative PCR (RT‑qPCR) analysis was employed to verify the results of the RNA sequencing in 45 cases of PTC. The dysregulated circRNA expression and clinicopathological characteristics were assessed and the potential roles of circRNAs in the cellular miRNA and mRNA network were predicted using bioinformatics analysis. The results demonstrated that, compared with normal tissues, a total of 53 circRNAs were dysregulated in tumour tissues, and 8 circRNAs were validated at the mRNA level (P |
| Databáze: | OpenAIRE |
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