Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation
| Autor: | Dimitri Barski, Dirk Ysebaert, Bernd Klosterhalfen, Christian Arndt, Thomas Otto, Albert Ramon, Mihály Boros, Holger Gerullis, Evangelos Georgas, Stephan Otto, Christoph Eimer |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
CD31
Pathology medicine.medical_specialty Biocompatibility Article Subject Connective tissue lcsh:Medicine General Biochemistry Genetics and Molecular Biology Prosthesis Implantation Animal model medicine Animals Longitudinal Studies Inflammation Sheep General Immunology and Microbiology Chemistry Macrophage infiltration Foreign-Body Reaction lcsh:R General Medicine Fascia Macrophage Activation Surgical Mesh medicine.disease medicine.anatomical_structure Early Diagnosis Treatment Outcome Cytokines Female Human medicine Foreign body Myofibroblast Research Article |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International BioMed research international |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Purpose.To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model.Materials and Methods.Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months.Results.Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min.Conclusion.The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation. |
| Databáze: | OpenAIRE |
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