Evaluation of the antitumoral potential of different nitric oxide-donating non-steroidal anti-inflammatory drugs (NO-NSAIDs) on human urological tumor cell lines
| Autor: | Sandra Huguenin, Jean-Pierre Riffaud, Marie-Claude Jaurand, Jocelyne Fleury-Feith, Manlio Bolla, Dominique K. Chopin, Francis Vacherot |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research Cell Antineoplastic Agents Pharmacology Nitric oxide Structure-Activity Relationship Prostate cancer chemistry.chemical_compound Cell Line Tumor medicine Humans Cytotoxic T cell Nitric Oxide Donors Sulindac Cyclooxygenase 2 Inhibitors Chemistry Anti-Inflammatory Agents Non-Steroidal Cell Cycle Prostatic Neoplasms Cell cycle medicine.disease medicine.anatomical_structure Urinary Bladder Neoplasms Oncology Cell culture Apoptosis medicine.drug |
| Zdroj: | Cancer Letters. 218:163-170 |
| ISSN: | 0304-3835 |
| Popis: | Our work aimed at identifying the antitumoral potential of new nitric oxide (NO)-releasing non-steroidal anti-inflammatory drug (NSAID) derivatives on human prostate and bladder carcinoma cell lines. Among all molecules tested, two sulindac derivatives, NCX 1102 ((Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl] methylene]-1H-indene-3-acetic acid 4-(nitrooxy)butyl ester) and NCX 1105 ((Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl] methylene]-1H-indene-3-acetic acid 6-(nitrooxymethyl)-2-methylpyrydyl ester hydrochloride), were the most cytotoxic compounds. In contrast to its parent molecule sulindac, cell cycle analysis showed that NCX 1102 led to cell accumulation in the G2-M transition stage in all cell lines, and induced apoptosis in five out of the six cell lines. Thus, NO-NSAIDs may be useful for the elaboration of new therapeutic strategies in the management of bladder and prostate cancer. |
| Databáze: | OpenAIRE |
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