Acute Effects of Nifedipine on Systolic and Diastolic Ventricular Function in Patients With Chronic Obstructive Pulmonary Disease
| Autor: | Philippe Dechamps, Nicole Naeije, Pierre Mols, Hamphrey Ham, Chi Hoang Huynh |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Nifedipine Administration Sublingual Diastole Cardiac index Hemodynamics Critical Care and Intensive Care Medicine Ventricular Function Left Afterload Internal medicine Humans Ventricular Function Medicine Lung Diseases Obstructive cardiovascular diseases Systole Aged business.industry Gated Blood-Pool Imaging Stroke Volume Stroke volume Middle Aged Myocardial Contraction medicine.anatomical_structure Anesthesia Ventricular Function Right cardiovascular system Cardiology Vascular resistance Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 103:1381-1384 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.103.5.1381 |
| Popis: | To evaluate how nifedipine influences systolic and diastolic ventricular function, the effects of 20 mg sublingual nifedipine were studied in 13 stable COPD patients. Nifedipine induced no change in mean pulmonary arterial pressure, decreased mean arterial pressure, pulmonary and systemic vascular resistance index, and increased heart rate and cardiac index. It also caused an increase in right and left ventricular ejection fractions. The end-diastolic volume index of both ventricles remained unchanged, whereas the end-systolic volume index tended to decrease without reaching a significant level, and the right ventricular contractility increased. After nifedipine administration, right and left ventricular compliance increased. This study suggests that short-term administration of nifedipine improves the systolic function by a decrease in ventricular afterload and an increase in ventricular contractility and increases the ventricular compliance by a reflex sympathetic stimulation and an afterload reduction. |
| Databáze: | OpenAIRE |
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