Procalcitonin: diagnostic value in systemic infections in chronic kidney disease or renal transplant patients
| Autor: | Dimitrie Siriopol, Raluca Dumea, Irina Mititiuc, Simona Hogas, Adrian Covic |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Calcitonin Male Nephrology Pathology medicine.medical_specialty Adolescent Calcitonin Gene-Related Peptide Urology medicine.medical_treatment Bacteremia Peritonitis Gastroenterology Procalcitonin End stage renal disease Peritoneal dialysis Young Adult Arteriovenous Shunt Surgical Interquartile range Internal medicine Pneumonia Bacterial medicine Humans Protein Precursors Kidney transplantation Dialysis Aged Aged 80 and over Pyelonephritis Enterocolitis business.industry Middle Aged medicine.disease Kidney Transplantation C-Reactive Protein ROC Curve Area Under Curve Kidney Failure Chronic Female business Peritoneal Dialysis Biomarkers Kidney disease |
| Zdroj: | International Urology and Nephrology. 46:461-468 |
| ISSN: | 1573-2584 0301-1623 |
| Popis: | Although procalcitonin (PCT) has been described as a marker of infection and inflammation, it has not been extensively studied in patients with chronic kidney disease (CKD), end stage renal disease, or renal transplant.PCT was routinely tested in 82 (56 dialyzed patients and 28 renal transplant recipients) consecutive cases with a strong clinical suspicion of infection, during a 6-month period, in a single referral unit.During the study period, 58/82 cases had confirmed infections as per definition. Patients with confirmed infections had higher values for PCT [median = 2.5 ng/mL, interquartile range (IR) = 0.9-5 ng/mL] than those without (median = 0.3 ng/mL, IR = 0.1-0.5 ng/mL), p0.001. Overall, for a cutoff value of 0.5 ng/mL, the sensitivity of the test was 93.1 % and the specificity 78.6.Our data indicate that significantly elevated PCT concentrations offer good sensitivity and specificity for the early diagnosis of systemic bacterial infection in patients with CKD. |
| Databáze: | OpenAIRE |
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