TRPV1 Activation by Anandamide via a Unique Lipid Pathway
| Autor: | Patricia H. Reggio, Diane L. Lynch, Chanté Muller, Dow P. Hurst |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Polyunsaturated Alkamides
General Chemical Engineering medicine.medical_treatment TRPV1 TRPV Cation Channels Arachidonic Acids Library and Information Sciences Transient receptor potential channel chemistry.chemical_compound Receptor Cannabinoid CB1 Cannabinoid Receptor Modulators medicine Binding site Receptor Chemistry musculoskeletal neural and ocular physiology General Chemistry Anandamide Endocannabinoid system Computer Science Applications Cell biology nervous system Capsaicin lipids (amino acids peptides and proteins) Cannabinoid psychological phenomena and processes Endocannabinoids |
| Zdroj: | Journal of Chemical Information and Modeling. 61:5742-5746 |
| ISSN: | 1549-960X 1549-9596 |
| DOI: | 10.1021/acs.jcim.1c00893 |
| Popis: | The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators. |
| Databáze: | OpenAIRE |
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