Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018
| Autor: | Péter Kertész, A. F. Nagy, Gábor Kemenesi, Károly Erdélyi, Gabor Toth, Tamás Bakonyi, Péter Malik, Ferenc Jakab, Anett Kuczmog, Balázs Somogyi, Anett Kepner, Orsolya Korbacska-Kutasi, Máté Martina, Orsolya Nagy, Tamás Süli, Brigitta Zana, Zsófia Lanszki, Mária Takács, Orsolya Fehér, Eszter Mezei, Petra Forgách, Krisztina Ursu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genes Viral viruses lcsh:QR1-502 Viral Nonstructural Proteins medicine.disease_cause goshawk epizootic lcsh:Microbiology Seroepidemiologic Studies Epidemiology Pathology Molecular Socioeconomics Antigens Viral Phylogeny Genetic diversification 2. Zero hunger virus isolation Phylogenetic tree Brief Report 3. Good health horse west nile encephalitis Infectious Diseases One Health Geography Encephalitis epidemiology West Nile virus medicine.medical_specialty 030106 microbiology Background factors Birds 03 medical and health sciences Viral Proteins Virology medicine Animals Humans Horses Epidemics Epizootic Hungary Public health medicine.disease Hawks 030104 developmental biology West Nile Fever co-circulation |
| Zdroj: | Viruses, Vol 12, Iss 1, p 123 (2020) Viruses |
| ISSN: | 1999-4915 |
| Popis: | The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of the virus to environmental conditions. The year of 2018 was characterized by an extraordinary increase in human and animal cases in the Central-Eastern European region, including Hungary. In a collaborative effort, we summarized and analyzed the genetic and serologic data of WNV infections from multiple Hungarian public health institutions, universities, and private organizations. We compared human and veterinary serologic data, along with NS5 and NS3 gene sequence data through 2018. Wild birds were excellent indicator species for WNV circulation in each year. Our efforts resulted in documenting the presence of multiple phylogenetic subclades with Balkans and Western-European progenitor sequences of WNV circulating among human and animal populations in Hungary prior to and during the 2018 epidemic. Supported by our sequence and phylogenetic data, the epidemic of 2018 was not caused by recently introduced WNV strains. Unfortunately, Hungary has no country-wide integrated surveillance system which would enable the analysis of related conditions and provide a comprehensive epidemiological picture. The One Health approach, involving multiple institutions and experts, should be implemented in order to fully understand ecological background factors driving the evolution of future epidemics. |
| Databáze: | OpenAIRE |
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