The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria
| Autor: | Junying Sun, Zheng Li, Chong Li, Hongbin Si, Yunqiao Yang, Fareed Qamar Memon, Geyin Zhang, Yunru Chen, Chongbo Lai, Qinmei Li, Kinza Tariq, Beibei Chai, Lei Guo, Shuaiyang Wang, Mingsheng Jiang, Lizhen Wang, Weiyu Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Article Subject DPPH medicine.medical_treatment 02 engineering and technology Polysaccharide Other systems of medicine 03 medical and health sciences chemistry.chemical_compound Immune system medicine Monosaccharide 030304 developmental biology chemistry.chemical_classification 0303 health sciences Bacterial disease ABTS Traditional medicine biology Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Complementary and alternative medicine 0210 nano-technology RZ201-999 Bacteria |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020) |
| ISSN: | 1741-427X |
| DOI: | 10.1155/2020/2719483 |
| Popis: | Semiaquilegia adoxoides (DC.) Makino is a herbal medicine and it is recorded that its water extract can be used to treat acute diseases caused by bacterial infections. In order to understand the polysaccharide of Semiaquilegia adoxoides (DC.) Makino (SMP), FT-IR and HPLC methods were performed to determine the basic chemical structure and monosaccharide compositions of SMP. The antioxidant capacity of SMP was analyzed by monitoring both the scavenging rate of DPPH and ABTS free radical. To investigate the effects of SMP on the acute bacterial disease, minimum inhibitory concentrations (MICs) of SMP on E. coli or S. aureus were detected; meanwhile, mice were administrated with SMP for 7 days and then infected with E. coli or S. aureus, and the parameters were measured at the 9th day. Results showed that SMP was a furanose which was mainly composed of glucose (60.3%) and had certain antioxidant activities. Both MIC values of SMP on E. coli and S. aureus were 250 ml/mL, which means that SMP has no direct antibacterial effects. The mice experiments revealed that SMP had potential effects on immunomodulatory by reducing WBC and the expression of serum IL-1, IL-6, and TNF-α and increasing IgM of E. coli or S. aureus infected mice. These findings supported the effect of Semiaquilegia adoxoides (DC.) Makino in folk use with scientific evidence. |
| Databáze: | OpenAIRE |
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