Optimizing the Use of TKIs in the Management of Chronic Myelogenous Leukemia
| Autor: | Karyn D. Ruiz-Cordell, Steven Haimowitz, Deborah L. Middleton, Linda Gracie-King |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.medical_specialty Alternative medicine Antineoplastic Agents 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Medical physics Molecular Targeted Therapy Disease management (health) Curriculum Protein Kinase Inhibitors Quality of Health Care business.industry Disease Management Imatinib Hematology medicine.disease Clinical research Oncology Nilotinib 030220 oncology & carcinogenesis Physical therapy Education Medical Continuing business Educational program medicine.drug Chronic myelogenous leukemia |
| Zdroj: | Clinical lymphoma, myelomaleukemia. 16(8) |
| ISSN: | 2152-2669 |
| Popis: | Introduction The goal of this study was to evaluate the proficiency of clinicians on multiple aspects of chronic myelogenous leukemia (CML) management, and to measure the impact of a multiple-activity educational curriculum on targeting those areas that presented the greatest clinical gaps in practice. Materials and Methods The findings show that before curriculum participation, clinicians demonstrated a high proficiency in their knowledge of first- and second-line therapies. However, they were challenged when asked to apply this knowledge to patient case studies. This clinical gap was then targeted through a multiple-activity educational curriculum platform that allowed participants to engage with nationally recognized CML experts about how to apply the latest clinical research and therapeutic advances to patient management. Results After evaluating these clinicians at the completion of the curriculum, the data showed that the program had successfully improved clinical performance regarding the treatment of patients requiring first-line therapies and treatment intensification in refractory CML (low-intermediate and high Sokal scores). However, participants remained challenged concerning the treatment of patients with intermediate Sokal scores who require treatment intensification after first-line therapy. The results also demonstrate the benefits of serial learning because participants who completed multiple activities achieved the greatest clinical performance gains from baseline. Conclusion The findings demonstrate how a focused and high-engagement educational program, in conjunction with an outcomes methodology that can measure its efficacy, can effectively evaluate and target clinical challenges and provide a model for future educational efforts. |
| Databáze: | OpenAIRE |
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