Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces
| Autor: | R, Feng, C, Rampon, Y P, Tang, D, Shrom, J, Jin, M, Kyin, B, Sopher, M W, Miller, C B, Ware, G M, Martin, S H, Kim, R B, Langdon, S S, Sisodia, J Z, Tsien |
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| Rok vydání: | 2001 |
| Předmět: |
Neuroscience(all)
Hippocampus Mice Transgenic Hippocampal formation Biology Amyloid beta-Protein Precursor Mice Prosencephalon Alzheimer Disease Memory Conditional gene knockout Presenilin-1 Animals RNA Messenger Brain Chemistry Mice Knockout Neurons Memory Disorders General Neuroscience Dentate gyrus Neurogenesis Membrane Proteins Electrophysiology Mice Inbred C57BL nervous system Knockout mouse Forebrain Mice Inbred CBA Memory consolidation Neuroscience |
| Zdroj: | Neuron. 32(5) |
| ISSN: | 0896-6273 |
| Popis: | To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and grew normally, but they exhibited a pronounced deficiency in enrichment-induced neurogenesis in the dentate gyrus. This reduction in neurogenesis did not result in appreciable learning deficits, indicating that addition of new neurons is not required for memory formation. However, our postlearning enrichment experiments lead us to postulate that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories. A chronic, abnormal clearance process in the hippocampus may conceivably lead to memory disorders in the mammalian brain. |
| Databáze: | OpenAIRE |
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