Immunohistochemistry and ultrastructure of somatostatin cells with special reference to the gastroenteropancreatic (GEP) system
| Autor: | Jürgen Metz, G. Mühlmann, W. G. Forssmann, G. E. Feurle, V. Helmstaedter |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Cell type Pathology Endocrinology Diabetes and Metabolism Cell Enteroendocrine cell Biology Cell morphology Islets of Langerhans Mice Endocrinology Cricetinae Internal medicine Diabetes Mellitus medicine Animals Humans Pancreas B cell Tupaiidae Rats medicine.anatomical_structure Somatostatin Cats Ultrastructure Digestive System |
| Zdroj: | Metabolism. 27:1179-1191 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(78)90039-2 |
| Popis: | Among the numerous endocrine cells in the gastroenteropancreatic (GEP) endocrine system, four main cell types have long been recognized: (1) the B cell, (2) the A cell, (3) the D cell, and (4) the EC cell. The existence of the D cell has been under considerable discussion although its histochemical and ultrastructural properties have been well established. Lacy and Greider1 note that gastrin is attributed to D cells and Solcia et al.2 state that “the function of the D cells remains obscure.” Initially the D cell was described by light microscopists,3–6 and later it was confirmed to be ultrastructurally a specific cell type distinct from A and B cells.7,8 An identical cell type was detected in the gut by histochemical staining properties9 and by ultrastructural features.10 Recently the detection of somatostatin as a new hormone of endocrine cells in the GEP system11–16 tremendously expanded our knowledge of the D cell and enabled its analysis morphologically and functionally by means of immunohistochemical staining for somatostatin. Although many aspects of the D cell morphology have been clarified, a number of questions and controversies still arise. The aim of this review is to summarize current knowledge of the D cell with respect to the results obtained in our laboratory. We mainly directed our research efforts toward the ultrastructural analysis of the D cell in the gut and pancreas and its exact distribution in the GEP system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|