Changes in Blood Macrophage Colony Stimulating Factor Levels after Cesarean Section in Normotensive Pregnancy and Preeclampsia
| Autor: | Takeyoshi Ohkura, Masatoshi Hayashi, Kazunori Hoshimoto |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Blood Pressure Preeclampsia Andrology Pre-Eclampsia Pregnancy Placenta medicine Humans reproductive and urinary physiology Eclampsia Cesarean Section Obstetrics business.industry Macrophage Colony-Stimulating Factor Case-control study Trophoblast General Medicine medicine.disease medicine.anatomical_structure Mean blood pressure Case-Control Studies Gestation Female business |
| Zdroj: | The American Journal of the Medical Sciences. 324:5-9 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/00000441-200207000-00002 |
| Popis: | Macrophage colony-stimulating factor (M-CSF) stimulates the proliferation and differentiation of placental trophoblasts and may regulate trophoblast invasion into the placental bed. M-CSF levels in peripheral blood show a significant increase in preeclampsia. Thus, the present study examined changes in blood levels of M-CSF before and after cesarean section and compared them between normotensive and preeclamptic pregnant women.Peripheral blood was collected before, 1 day after, and 10 days after cesarean section from 27 women, 12 of whom were preeclamptic pregnant patients with a mean blood pressure of 162/98 mm Hg and 15 were age- and gestational age-matched normotensive pregnant women (normotensive control subjects). Peripheral blood was also collected once from 15 age-matched healthy, normal cycling women (nonpregnant control subjects). M-CSF level was determined by the sandwich enzyme-linked immunosorbent assay (ELISA) method using 3 antibodies.In normotensive and preeclamptic pregnancies, the M-CSF levels increased significantly (P0.01) 1 day after surgery but then decreased significantly (P0.01) at 10 days after surgery. Before and 1 day after surgery, the M-CSF levels were significantly higher (P0.01) in preeclamptic patients than in normotensive control subjects, but not at 10 days after surgery.The blood M-CSF levels were significantly higher in preeclampsia than in normotensive pregnancies, before cesarean section. The M-CSF levels in the circulation at 1 day after surgery increased significantly. The increase was about 270 U/mL net and at similar levels in 2 groups. Thus, increases in M-CSF levels after cesarean section may occur via similar mechanisms in normotensive and preeclamptic pregnancies. The M-CSF level in normotensive pregnancies and preeclampsia decreased and returned to the normal level at 10 days after cesarean section. |
| Databáze: | OpenAIRE |
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