Plasma testosterone and androstenedione levels during monitored induction of ovulation in infertile women with 'simple' amenorrhoea and with the polycystic ovary syndrome
| Autor: | G. I. M. Swyer, Ewa Radwanska, H. H. G. Mcgarrigle, Daphne M. Lawrence |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Ovulation endocrine system medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject Chorionic Gonadotropin Human chorionic gonadotropin Clomiphene Endocrinology Pregnancy Internal medicine medicine Humans Testosterone Androstenedione Amenorrhea Progesterone media_common Estradiol business.industry Androgen Polycystic ovary Female medicine.symptom Gonadotropin business Infertility Female hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | Clinical endocrinology. 5(6) |
| ISSN: | 0300-0664 |
| Popis: | The significance of androgen levels for the successful induction of ovulation was evaluated in 27 patients with amenorrhea-oligomenorrhea and 18 patients with polycystic ovary (PCO). Induction of ovulation was attempted with clomiphene human menopausal gonadotropin and human chorionic gonadotropin and the course of therapy was monitored by measurement of plasma estradiol testosterone androstenedione and progesterone. Subjects with PCO had significantly higher pretreatment and treatment plasma androgen levels than women with simple amenorrhea (p less than .01 to p less than .001). In cases where ovulation was successfully induced the pregnancy rate for subjects with PCO syndrome and elevated androgen levels was 21% while that for patients with simple amenorrhea was 75%. The results strongly suggest that elevated levels of plasma androgens may prevent conception in some patients who have successfully responded to ovulation therapy. |
| Databáze: | OpenAIRE |
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