Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy
| Autor: | Angela Norman, Stuart Martin, John Sheehan, Peter C. Griffiths, Ian Dexter, Glenn C. Telling, Christopher M. Vickery, Katy E. Beck, Thomas M. Holder, Sarah Marsh, Paul R. Webb, Paul Holden, Christina Wilson, Amanda Schneider, Leigh Thorne, Marion Simmons, Mark P. Dagleish, Emma Popescu, John Spiropoulos, Jane M. Plater, Margaret Denyer, Richard Lockey |
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| Rok vydání: | 2013 |
| Předmět: |
Genetically modified mouse
Central Nervous System Male Prions Bovine spongiform encephalopathy animal diseases Immunology Prion strain Mice Transgenic Biology Microbiology Disease susceptibility Mice Species Specificity Virology medicine Animals Prion protein Deer Chronic wasting disease medicine.disease Mice transgenic nervous system diseases Encephalopathy Bovine Spongiform Disease Models Animal Insect Science Wasting Disease Chronic Cattle Female Disease Susceptibility |
| Zdroj: | Journal of virology. 88(3) |
| ISSN: | 1098-5514 |
| Popis: | Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536 +/− , to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536 +/− mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer. |
| Databáze: | OpenAIRE |
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