A double‐blind, placebo‐controlled randomized trial of skin‐lightening cream containing lycopene and wheat bran extract on melasma
| Autor: | Mona Safaezadeh, Neda Bavarsad, Seyed Mahmoud Latifi, Mohammad Ali Mapar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Dietary Fiber
medicine.medical_specialty Melasma Tyrosinase Skin Cream Dermatology Placebo Gastroenterology Skin Discoloration Melanosis law.invention 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Lycopene 0302 clinical medicine Randomized controlled trial law Internal medicine Humans Medicine Carotenoid chemistry.chemical_classification Plant Extracts business.industry food and beverages medicine.disease Hyperpigmentation Treatment Outcome chemistry 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | Journal of Cosmetic Dermatology. 20:1795-1800 |
| ISSN: | 1473-2165 1473-2130 |
| Popis: | OBJECTIVE Melasma is an acquired hyperpigmentation disorder, and reactive oxygen species play important role in regulating melanin synthesis. Lycopene is one of the most effective oxygen neutralizers among tomato-derived carotenoids. Also, hydroquinone is a compound that has been used for the treatment of hyperpigmentation by mechanism of tyrosinase inhibition and can be found in wheat. METHODS An appropriate cream formulation containing 0.05% tomato lycopene and 3.45% wheat bran extract was prepared, and physicochemical characterization was performed. The prepared formulations were applied twice a day for three months in combination with SPF = 30 sunscreen by 22 patients diagnosed with melasma. MASI score in two groups was evaluated at weeks 0, 3, 6, 9, and 12 and 1 month after the treatment. RESULTS The prepared formulation shows smooth and homogeneous appearance with suitable spreadability and viscosity. The MASI score of intervention group from the sixth week until the end of the treatment was significantly decreased compared to the onset of the treatment (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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