Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)

Autor: Pierre-Henri Ducluzeau, Christelle Ramé, Klaudia Błaszczyk, Pascal Froment, Patrycja Kurowska, Joëlle Dupont, Anthony Estienne, Agnieszka Rak, Alice Bongrani
Přispěvatelé: Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), CHU Bretonneau, Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
AMPK
endocrine system diseases
[SDV]Life Sciences [q-bio]
Hypothalamic–pituitary–gonadal axis
Apoptosis
AMP-Activated Protein Kinases
Primary Ovarian Insufficiency
Biochemistry
pituitary
0302 clinical medicine
Endocrinology
Ovarian Follicle
energy metabolism
Female fertility
hypothalamus
biology
TOR Serine-Threonine Kinases
Polycystic ovary
female genital diseases and pregnancy complications
Premature ovarian failure
medicine.anatomical_structure
Hypothalamus
Pituitary Gland
mTOR
Female
Polycystic Ovary Syndrome
medicine.medical_specialty
endocrine system
030209 endocrinology & metabolism
Ovary
03 medical and health sciences
Internal medicine
medicine
Animals
Humans
Ovarian follicle
Molecular Biology
Sirtuin 1
Energy metabolism
medicine.disease
030104 developmental biology
Fertility
Pituitary
SIRTUIN 1
biology.protein
ovary
female fertility
Zdroj: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2021, 521, pp.1-12. ⟨10.1016/j.mce.2020.111113⟩
ISSN: 0303-7207
Popis: International audience; In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including the hypothalamic GnRH neuronal network, the pituitary gonadotropin secretion and the ovarian follicle growth and steroidogenesis. Several hormones and neuropeptides or metabolites are important signals between energy balance and reproduction. These energy sensors mediate their action on reproductive cells through specific kinases or signaling pathways. This review focuses on the role of three main enzymes-specifically, mTOR, AMPK, and SIRT1 at the hypothalamic pituitary and ovarian axis in normal female fertility and then we discuss their possible involvement in some women reproductive disorders known to be associated with metabolic complications, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF).
Databáze: OpenAIRE
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