Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy
| Autor: | Lan-Feng Dong, Olivia J. Holland, Vinod Gopalan, Jiri Neuzil |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Programmed cell death
Citric Acid Cycle Antineoplastic Agents Review Mitochondrion Biology medicine.disease_cause Catalysis anti-cancer strategy lcsh:Chemistry Inorganic Chemistry Neoplasms medicine Humans Molecular Targeted Therapy Physical and Theoretical Chemistry mitochondrial targeting lcsh:QH301-705.5 Molecular Biology Spectroscopy Clinical Trials as Topic Organic Chemistry Cancer General Medicine medicine.disease Computer Science Applications Cell biology Mitochondria Citric acid cycle Gene Expression Regulation Neoplastic lcsh:Biology (General) lcsh:QD1-999 Electron Transport Chain Complex Proteins Drug Resistance Neoplasm Cancer cell drug delivery Disease Progression Carcinogenesis Oxidation-Reduction Function (biology) Tamoxifen medicine.drug mitocans Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 7941, p 7941 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with a great advantage of potentially overcoming drug resistance. Mitocans, exemplified by mitochondrially targeted vitamin E succinate and tamoxifen (MitoTam), selectively target cancer cell mitochondria and efficiently kill multiple types of cancer cells by disrupting mitochondrial function, with MitoTam currently undergoing a clinical trial. |
| Databáze: | OpenAIRE |
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