The emerging role of human TBK1 in virus-induced autophagy
| Autor: | Sancho-Shimizu Vanessa, Ahmad Liyana |
|---|---|
| Přispěvatelé: | Medical Research Foundation, Brunei Darussalam High Commission |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biochemistry & Molecular Biology TBK1 Inflammation Herpesvirus 1 Human Biology Protein Serine-Threonine Kinases 0601 Biochemistry and Cell Biology Viral infection Virus 03 medical and health sciences TANK-binding kinase 1 Interferon medicine Autophagy Humans RNA Small Interfering Child Molecular Biology Cells Cultured Science & Technology 030102 biochemistry & molecular biology Cell Biology interferon Fibroblasts HSV-1 infection Cell biology Toll-Like Receptor 3 Interferon production Adaptor Proteins Vesicular Transport 030104 developmental biology Poly I-C inflammation Host-Pathogen Interactions Mutation Commentary Interferon Regulatory Factor-3 Encephalitis Herpes Simplex Interferons medicine.symptom CNS Life Sciences & Biomedicine Microtubule-Associated Proteins Function (biology) medicine.drug Signal Transduction |
| Zdroj: | Autophagy |
| ISSN: | 1554-8635 1554-8627 |
| Popis: | Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Lastly, we highlight the potential implication of TBK1 in the management of inflammation through autophagy, particularly within the central nervous system. |
| Databáze: | OpenAIRE |
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