Phenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fat
| Autor: | Sharon R. Browning, Alex Ankersmit-Udy, Sarah D. Berry, Klaus Lehnert, Stephen R. Davis, Linda F. Adams, Russell G. Snell, Alastair K. H. MacGibbon, H. E. Ward, Pisana Rawson, B.L. Harris, Yvonne van der Does, Elizabeth Marie Beattie, Gwyneth A. Verkerk, Richard J. Spelman, CA Ford, Natalie Louise Thomas, T. William Jordan, Alayna Katie Burrett |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Saturated fat Population Mutation Missense Biology Selective breeding Polymorphism Single Nucleotide Article Gene mapping Genetic variation Animals Diacylglycerol O-Acyltransferase education Genetic Association Studies Genetics Genetic diversity education.field_of_study Multidisciplinary Base Sequence Fatty Acids food and beverages Lipid Metabolism Pedigree Milk Phenotype Mutation (genetic algorithm) Cattle Female Gene pool |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep08484 |
| Popis: | Selective breeding has strongly reduced the genetic diversity in livestock species, and contemporary breeding practices exclude potentially beneficial rare genetic variation from the future gene pool. Here we test whether important traits arising by new mutations can be identified and rescued in highly selected populations. We screened milks from 2.5 million cows to identify an exceptional individual which produced milk with reduced saturated fat content, and improved unsaturated and omega-3 fatty acid concentrations. The milk traits were transmitted dominantly to her offspring, and genetic mapping and genome sequencing revealed a new mutation in a previously unknown splice enhancer of the DGAT1 gene. Homozygous carriers show features of human diarrheal disorders, and may be useful for the development of therapeutic strategies. Our study demonstrates that high-throughput phenotypic screening can uncover rich genetic diversity even in inbred populations, and introduces a novel strategy to develop novel milks with improved nutritional properties. |
| Databáze: | OpenAIRE |
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