Chronic high-fat diet affects food-motivated behavior and hedonic systems in the nucleus accumbens of male rats
| Autor: | Danusa Mar Arcego, Carla Dalmaz, Cecilia Scorza, Ana Paula Toniazzo, Rachel Krolow, Gustavo Costa, Carine Lampert, Camilla Lazzaretti, Emily dos Santos Garcia |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Dopamine 030209 endocrinology & metabolism Nucleus accumbens Biology Diet High-Fat Nucleus Accumbens 03 medical and health sciences Eating 0302 clinical medicine Neurochemical Internal medicine medicine Animals Obesity General Psychology 030109 nutrition & dietetics Nutrition and Dietetics digestive oral and skin physiology Dopaminergic food and beverages Feeding Behavior medicine.disease Endocannabinoid system Rats Endocrinology Opioid Cannabinoid medicine.drug |
| Zdroj: | Appetite. 153 |
| ISSN: | 1095-8304 |
| Popis: | Environmental variations can influence eating and motivated behaviors, as well as the brain's feeding circuits to predisposing overweight and obesity. The identification of mechanisms through which a long-term consumption of caloric-dense palatable foods and its association with early life stress can cause neuroadaptations and possible modify motivational behaviors are relevant to elucidate the mechanisms associated with obesity. Here, we investigated the long-term effects of a chronic high-fat diet (HFD), and its interaction with early social isolation on hedonic feeding responses in adult rats. Rats were subjected, or not, to social isolation between postnatal days 21–28 and were fed a control diet or HFD, for 10 weeks post weaning. Hedonic feeding behavior was evaluated during adulthood and parameters related to the dopaminergic, cannabinoid, and opioid systems were measured in the nucleus accumbens. Animals with chronic HFD intake were less motivated to obtain sweet palatable foods. This reduced motivation did not appear to be associated with less pleasure upon tasting sweet food, as no alteration in reactivity to sweet taste was observed. Interestingly, the animals receiving HFD presented decreased immunocontents of the D1 and CB1 receptors, while the stressed group displayed a reduction in dopamine turnover. In summary, chronic HFD causes a significant motivational impairment for sweet palatable foods; these changes may be associated with a decreased dopaminergic and cannabinoid neurotransmission in the nucleus accumbens. In contrast, a brief social isolation during the prepubertal period was unable to alter the behavioral parameters studied but caused a decreased dopaminergic turnover in the nucleus accumbens of adult rats. These findings highlight the importance of long-term HFD exposure on the modulation of hedonic feeding behavior and related neurochemical systems. |
| Databáze: | OpenAIRE |
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