Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses
| Autor: | Marco J. Russo, Ekaterina Likhtik, Joshua A. Gordon, Stanley Aladi, Baylor C. Brangers, C. Daniel Salzman, Richard Axel, Joseph M. Stujenske, Felicity Gore, Edmund C. Schwartz |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Appetitive Behavior Critical structure Behavior Animal Extramural Basolateral Nuclear Complex Biochemistry Genetics and Molecular Biology(all) Conditioning Classical Conditioned response Biology Amygdala Article General Biochemistry Genetics and Molecular Biology Mice Inbred C57BL Mice medicine.anatomical_structure Reward medicine Animals Learning Valence (psychology) Sensory cue Neuroscience Basolateral amygdala |
| Zdroj: | Cell. 162(1):134-145 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2015.06.027 |
| Popis: | SummaryStimuli that possess inherently rewarding or aversive qualities elicit emotional responses and also induce learning by imparting valence upon neutral sensory cues. Evidence has accumulated implicating the amygdala as a critical structure in mediating these processes. We have developed a genetic strategy to identify the representations of rewarding and aversive unconditioned stimuli (USs) in the basolateral amygdala (BLA) and have examined their role in innate and learned responses. Activation of an ensemble of US-responsive cells in the BLA elicits innate physiological and behavioral responses of different valence. Activation of this US ensemble can also reinforce appetitive and aversive learning when paired with differing neutral stimuli. Moreover, we establish that the activation of US-responsive cells in the BLA is necessary for the expression of a conditioned response. Neural representations of conditioned and unconditioned stimuli therefore ultimately connect to US-responsive cells in the BLA to elicit both innate and learned responses. |
| Databáze: | OpenAIRE |
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