Assessment of Cardiovascular Function and Microvascular Permeability in a Conscious Rat Model of Alcohol Intoxication Combined with Hemorrhagic Shock and Resuscitation
| Autor: | Natascha G. Alves, Jerome W. Breslin, Travis M. Doggett, Sarah Y. Yuan, Srinivas M. Tipparaju, Jared Tur |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Resuscitation Hemodynamics Vascular permeability Shock Hemorrhagic 030204 cardiovascular system & hematology Article Microcirculation Capillary Permeability 03 medical and health sciences 0302 clinical medicine Alcohol intoxication Internal medicine Animals Humans Medicine Depression (differential diagnoses) business.industry 030208 emergency & critical care medicine medicine.disease Rats Disease Models Animal Traumatic injury Shock (circulatory) Cardiology medicine.symptom business Alcoholic Intoxication |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493975242 |
| DOI: | 10.1007/978-1-4939-7526-6_6 |
| Popis: | Hypotension, cardiac depression, and elevated microvascular permeability are known problems that complicate resuscitation of patients following traumatic injury, particularly those who are also intoxicated from alcohol consumption. A conscious rat model of combined alcohol intoxication and hemorrhagic shock has been used to study the hemodynamic mechanisms involved. Here, we describe using this model to study microvascular leakage and cardiac electrical activity. |
| Databáze: | OpenAIRE |
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