Regional Cerebral Abnormalities Measured by Frequency-Domain Near-Infrared Spectroscopy in Pediatric Patients During Extracorporeal Membrane Oxygenation
| Autor: | Donald Potter, Christopher L. Jenks, Fenghua Tian, Darryl K. Miles, Lakshmi Raman |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Light medicine.medical_treatment Neurological morbidity Biomedical Engineering Biophysics Bioengineering 030204 cardiovascular system & hematology Article Decreased density Biomaterials 03 medical and health sciences Extracorporeal Membrane Oxygenation 0302 clinical medicine 030225 pediatrics Internal medicine medicine Extracorporeal membrane oxygenation Humans Scattering Radiation Significant risk Respiratory system Child Brain Diseases Spectroscopy Near-Infrared business.industry Critically ill Infant Newborn Infant Cardiorespiratory fitness General Medicine Surgery surgical procedures operative Cardiology Female Brain matter business |
| Zdroj: | ASAIO Journal. 63:e52-e59 |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/mat.0000000000000453 |
| Popis: | Extracorporeal membrane oxygenation (ECMO) is a form of advanced cardiorespiratory support provided to critically ill patients with severe respiratory or cardiovascular failure. While children undergoing ECMO therapy have significant risk for neurological morbidity, currently there is a lack of reliable bedside tool to detect the neurologic events for patients on ECMO. This study assessed the feasibility of frequency-domain near-infrared spectroscopy (NIRS) for detection of intracranial complications during ECMO therapy. The frequency-domain NIRS device measured the absorption coefficient (μ(a)) and reduced scattering coefficient (μ(s)′) at six cranial positions from seven pediatric patients (0–16 years) during ECMO support and five healthy controls (2–14 years). Regional abnormalities in both absorption and scattering were identified among ECMO patients. A main finding in this study is that the abnormalities in scattering appear to be associated with lower-than-normal μ(s)′ values in regional areas of the brain. Because light scattering originates from the intracellular structures (such as nuclei and mitochondria), a reduction in scattering primarily reflects loss or decreased density of the brain matter. The results from this study indicate a potential to use the frequency-domain NIRS as a safe and complementary technology for detection of intracranial complications during ECMO therapy. |
| Databáze: | OpenAIRE |
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