Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility
| Autor: | Nirali Rathwa, Roma Patel, A. V. Ramachandran, Sayantani Pramanik Palit, Rasheedunnisa Begum |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male 0106 biological sciences medicine.medical_specialty endocrine system diseases Adipokine Single-nucleotide polymorphism Type 2 diabetes Biology Polymorphism Single Nucleotide 01 natural sciences Body Mass Index 03 medical and health sciences Internal medicine Genotype Genetics medicine Humans Resistin Dyslipidemias 030304 developmental biology 0303 health sciences Haplotype nutritional and metabolic diseases Middle Aged medicine.disease Cholesterol Endocrinology Diabetes Mellitus Type 2 Female Body mass index Dyslipidemia 010606 plant biology & botany |
| Zdroj: | Genomics. 111:980-985 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/j.ygeno.2018.06.005 |
| Popis: | Resistin, an adipokine, is involved in obesity and Type 2 Diabetes (T2D). The current study evaluates the association between RETN polymorphisms (−638 G/A, −420C/G & −358 G/A) and the risk towards T2D. Controls and T2D patients were enrolled from Gujarat, India. Polymorphisms of RETN were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. For the genotype-phenotype correlation analysis Fasting Blood Glucose (FBG), Body Mass Index (BMI) and plasma lipid profile were used. Plasma levels of resistin were assayed by ELISA. Our study suggests an association of RETN −420C/G polymorphism with T2D risk. The CC genotype of RETN −420C/G polymorphism was found to be associated with FBG, BMI, and total cholesterol. Plasma resistin levels were found to be significantly increased in diabetic patients as compared to controls. Our findings suggest −420C/G polymorphism of RETN as an important factor which could pose a powerful risk towards T2D susceptibility. |
| Databáze: | OpenAIRE |
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