Identifying Unique Versus Shared Pre- and Perinatal Risk Factors for ASD and ADHD Using a Simplex-Multiplex Stratification

Autor: Nanda Rommelse, Marlot J. Burmanje, Catharina A. Hartman, Barbara Franke, Jan K. Buitelaar, Anoek M. Oerlemans
Přispěvatelé: Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Proband
Male
Autism Spectrum Disorder
Perinatal risk
AUTISM SPECTRUM DISORDERS
CHILDREN
FAMILIES
Developmental psychology
0302 clinical medicine
DEFICIT-HYPERACTIVITY DISORDER
Pregnancy
Risk Factors
Surveys and Questionnaires
Developmental and Educational Psychology
Young adult
Child
POPULATION
education.field_of_study
COMPLICATIONS
05 social sciences
PSYCHOPATHOLOGY
3. Good health
Simplex-multiplex stratification
Psychiatry and Mental health
Autism spectrum disorder
COMPREHENSIVE METAANALYSIS
Child
Preschool
Prenatal Exposure Delayed Effects
Prenatal and perinatal risk factors
Female
Psychology
050104 developmental & child psychology
Psychopathology
Adult
medicine.medical_specialty
Attention-Deficit/Hyperactivity Disorder (ADHD)
PRETERM BIRTH
Adolescent
Offspring
Population
Autism Spectrum Disorders (ASD)
behavioral disciplines and activities
Article
03 medical and health sciences
Young Adult
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
EXPOSURE
Psychiatry
education
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
medicine.disease
Attention Deficit Disorder with Hyperactivity
Etiology
030217 neurology & neurosurgery
Zdroj: Journal of Abnormal Child Psychology
Journal of Abnormal Child Psychology, 44(5), 923-935. SPRINGER/PLENUM PUBLISHERS
Journal of Abnormal Child Psychology, 44, 5, pp. 923-35
Journal of Abnormal Child Psychology, 44, 923-35
ISSN: 1573-2835
0091-0627
Popis: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. Besides shared genetic factors, pre- and perinatal risk factors (PPFs) may determine if ASD, ADHD, or the combination of both disorders becomes manifest. This study aimed to test shared and unique involvement of PPFs for ASD and ADHD, using an approach that stratifies the sample into affected/unaffected offspring and single-incidence (SPX) versus multi-incidence (MPX) families. Pre- perinatal data based on retrospective parent-report were collected in 288 children (71 % males) from 31 SPX and 59 MPX ASD families, 476 children (65 % males) from 31 SPX and 171 MPX ADHD families, and 408 control children (42 % males). Except for large family size and more firstborns amongst affected offspring, no shared PFFs were identified for ASD and ADHD. PPFs predominantly related to ASD (maternal infections and suboptimal condition at birth) were more often reported in affected than unaffected siblings. PPFs associated with ADHD (low parental age, maternal diseases, smoking and stress) were shared between affected and unaffected siblings. Firstborn-ship was more frequent in SPX than MPX ASD probands. Our results suggest that the co-morbidity of ASD and ADHD is not likely explained by shared PPFs. Instead, PPFs might play a crucial role in the developmental pathways leading up to either disorder. PPFs in ADHD appear to index an increased shared risk, whereas in ASD PPFs possibly have a more determining role in the disorder. SPX-MPX stratification detected possible etiological differences in ASD families, but provided no deeper insight in the role of PPFs in ADHD. Electronic supplementary material The online version of this article (doi:10.1007/s10802-015-0081-0) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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