Adiponectin is independently associated with glycosylated haemoglobin
| Autor: | José Manuel Fernández-Real, Roser Casamitjana, Wifredo Ricart, Elías Delgado, Shinji Kihara, Tohru Funahashi, Patricia Botas-Cervero, Abel López-Bermano |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Statistics as Topic Population Biology Carbohydrate metabolism Endocrinology Insulin resistance Internal medicine Diabetes mellitus Glucose Intolerance medicine Humans education Aged Glycated Hemoglobin education.field_of_study Adiponectin Proteins nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Cross-Sectional Studies Blood pressure Diabetes Mellitus Type 2 Metabolic control analysis Intercellular Signaling Peptides and Proteins Female Insulin Resistance Body mass index |
| Zdroj: | European Journal of Endocrinology. :201-205 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1500201 |
| Popis: | Background: In humans, adiponectin has been demonstrated to circulate in inverse proportion to the degree of insulin resistance. Objective: To investigate the association between adiponectin and glycosylated haemoglobin (HbA 1c ) in a population-based study. Design and methods: Two hundred and ninety-seven individuals aged 30-75 years were enrolled in a cross-sectional study. They included patients with type 2 (non-insulin-dependent) diabetes mellitus and stable, good metabolic control (n = 32) and individuals with glucose intolerance (n = 54). Adiponectin was measured using a sandwich enzyme-linked immunosorbent assay (intra-assay and interassay coefficients of variation 3.3 and 7.4% respectively). Results: Adiponectin correlated with age (r = 0.161; P = 0.006). body mass index (r = -0.197: P = 0.001), diastolic blood pressure (r = -0.181; P = 0.005), fasting glucose and HbA 1c (r = -0.251 and r = -0.22 respectively; P < 0.0001), high-density lipoprotein cholesterol (r = 0.442; P < 0.001) and serum triglycerides (r = - 362: P < 0.001). In multiple regression analysis, sex, age, fasting and post-load glucose, and adiponectin independently contributed to 40% of the variance in HbA 1c . Among individuals with normal glucose tolerance, fasting glucose (P = 0.0033), post-load glucose (P = 0.0015), age (P = 0.001) and adiponectin (P = 0.0083) independently contributed to 21% of the variance in HbA 1c . Conclusion: Adiponectin is significantly associated with altered glucose metabolism and independently contributes to the variance of HbA 1c in a population-based manner. |
| Databáze: | OpenAIRE |
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