A multicenter real‐world review of 10 kH z SCS outcomes for treatment of chronic trunk and/or limb pain

Autor:	Leonardo Kapural, Jeyakumar Subbaroyan, Dawood Sayed, Thomas Stauss, Abdul Ghaaliq Lalkhen, Gernot Surges, William S. Rosenberg, Bradford E. Gliner, Anand Rotte, Deborah R. Edgar, Mohammad Maarouf, Faycal El Majdoub, Richard Bundschu, Martin Bettag, Nileshkumar Patel
Rok vydání:	2019
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty MEDLINE Therapeutics 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Quality of life medicine Humans Pain Management Therapy efficacy Research Articles Pain Measurement Retrospective Studies Spinal Cord Stimulation business.industry General Neuroscience Torso Extremities Retrospective cohort study Middle Aged Trunk Treatment Outcome 030104 developmental biology Back Pain Meta-analysis Concomitant Quality of Life Physical therapy Female Observational study Neurology (clinical) Chronic Pain business 030217 neurology & neurosurgery Research Article Follow-Up Studies
Zdroj:	Annals of Clinical and Translational Neurology
ISSN:	2328-9503
DOI:	10.1002/acn3.720
Popis:	Objectives High‐frequency spinal cord stimulation (HF‐SCS) at 10 kHz has proven to be efficacious in the treatment of chronic back and leg pain in a randomized, controlled, trial (SENZA‐RCT). However, large observational studies have yet to be published. Therefore, we performed a real‐world, multicenter, retrospective, review of therapy efficacy in 1660 patients with chronic trunk and/or limb pain. Methods Data were collected in a real‐world environment and retrospectively sourced from a global database. Included patients were trialed and/or permanently implanted with HF‐SCS at 10 kHz between April 2014 and January 2018. We evaluated responder rates at 3, 6, and 12 months post‐implantation. Response was defined as ≥50% pain relief from baseline. A last visit analysis included responder rate along with overall change in function, sleep, quality of life, and medication intake versus baseline. Results Eighty‐four percent of our HF‐SCS‐treated patients had both chronic back and leg pain. At least 70% of patients reported response to therapy throughout 12 months of follow‐up. This sustained responder rate was corroborated by the last visit value (74.1%). Most patients reported concomitant improvements in function (72.3%), sleep (68.0%), and quality of life (90.3%) at their last visit versus baseline. Thirty‐two percent of patients reported decreased medication intake at their last visit. Interpretation Sustained and effective pain relief was experienced by >70% of our HF‐SCS‐treated patients, consistent with the findings of a previously published randomized, controlled, trial. Our review provides complementary evidence to support the treatment of chronic back and leg pain with this therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995081b8914a35e95de7a2153fae1484 https://doi.org/10.1002/acn3.720 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.