Secretory and vascular effects of adrenomedullin in gastric ulcer: role of CGRP- and adrenomedullin-receptors
| Autor: | Vincenza Maria Catena Cutuli, A. Bianchi, Giuseppa Martinez, Salvatore Salomone, Agata Prato, Matilde Amico-Roxas, Antonina Caruso, Giuseppe Clementi |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Receptors Peptide Physiology Neuropeptide Calcitonin gene-related peptide Biochemistry Adrenomedullin Cellular and Molecular Neuroscience Endocrinology Internal medicine Gastric mucosa medicine Animals Humans Stomach Ulcer Receptors Adrenomedullin Receptor Inhibitory effect Chemistry Stomach digestive oral and skin physiology digestive system diseases Rats medicine.anatomical_structure Peptides hormones hormone substitutes and hormone antagonists Gastric acid output Receptors Calcitonin Gene-Related Peptide |
| Zdroj: | Peptides. 24:1175-1180 |
| ISSN: | 0196-9781 |
| Popis: | Adrenomedullin prevents damage of gastric mucosa in either reserpine-treated or pylorus-ligated rats. Pre-treatment with CGRP(8-37) resulted in a decrease of the gastro-protective effect of adrenomedullin in both models and reversed the inhibitory effect of adrenomedullin on gastric acid output in the pylorus-ligated rats. These adrenomedullin actions were less effectively modified by pre-treatment with adrenomedullin(22-52). These data suggest that the anti-ulcer effect of adrenomedullin is mainly related to its anti-secretory action, presumably mediated through CGRP-receptors. |
| Databáze: | OpenAIRE |
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