A Non-Invasive Method to Assess Cerebral Perfusion Pressure in Geriatric Patients with Suspected Cerebrovascular Disease
| Autor: | Deyu Yang, Qi Li, Peng Xie, Zhiwei Li, Bo Liu, Peng He, Kewei Li, Nan Deng, Chunchang Qin |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Patients Carotid Artery Common Science Carotid arteries Vertebral artery Hemodynamics Geriatric Nursing Heart Rate medicine.artery Internal medicine Heart rate Medicine Humans Cerebral perfusion pressure Vertebral Artery Aged Demography Aged 80 and over Multidisciplinary business.industry Non invasive Middle Aged medicine.disease Stenosis Cerebrovascular Disorders Blood pressure Cerebrovascular Circulation Cardiology Female business Algorithms Software Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 3, p e0120146 (2015) |
| ISSN: | 1932-6203 |
| Popis: | BackgroundCerebral perfusion pressure (CPP) can adversely impact cerebrovascular hemodynamics but cannot be practically measured in most clinical settings. Here, we aimed to establish a representative mathematical model for CPP in geriatric patients with suspected cerebrovascular disease.MethodsA total of 100 patients (54 males and 46 females between 60-80 years of age) with suspected cerebrovascular disease and no obvious cerebrovascular stenosis were selected for invasive CPP monitoring via catheterization of the middle segment of the common carotid arteries and openings of the vertebral arteries bilaterally. Curves were function-fitted using MATLAB 7.0, and data was statistically processed by SPSS 20.0.ResultsMATLAB 7.0 constructed eighth-order Fourier functions that fit all recorded CPP curves. Since the coefficients of the 100 functions were significantly different, all functions were standardized to derive one representative function. By manipulating the heart rate and maximum/minimum CPP of the representative function, estimated CPP curves can be constructed for patients with differing heart rates, intracranial pressures (ICPs) and blood pressures.ConclusionsCPP can be well-modeled through an eighth-order Fourier function that can be constructed from a patient's brachial artery blood pressure (BABP), ICP and heart rate. This function is representative of geriatric patients with cerebrovascular disease and can be used in the future study of cerebral hemodynamics. |
| Databáze: | OpenAIRE |
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