Patterns of cocaine binging: Effect on pregnancy
| Autor: | Salih Yasin, Marleny Martinez, Larry LaVoie, Diana Palow, Gene Burkett |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Substance-Related Disorders Cocaine Pregnancy medicine Humans Risk factor Psychiatry Fetal Death Analysis of Variance Perinatal complications business.industry Infant Newborn Pregnancy Outcome Obstetrics and Gynecology medicine.disease Pregnancy Complications Substance abuse Infant Small for Gestational Age Gestation Small for gestational age Female Analysis of variance business Infant Premature Demography |
| Zdroj: | American Journal of Obstetrics and Gynecology. 171:372-379 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(94)70037-0 |
| Popis: | The purpose of this study was to determine how cocaine and crack binging affected perinatal complications.Between Jan. 1 and Dec. 31, 1989, patterns of cocaine-crack binging and perinatal consequences in 905 pregnant women from multiethnic, multiracial, inner-city populations were studied. Binging cycles reflect the chaotic lifestyle of drug abuse and multiple obstetric at-risk cofactors as integral parts of binging and are more accurately defined than amount of drugs consumed.Binging patterns in 905 pregnant women who use cocaine-crack as their primary drug were as follows: group 1, 78 women with "erratic" binging that is variable in intervals, duration, and amounts but who are very aggressive drug seekers; group 2, 67 women who binged daily; group 3, 760 women who binged in cycles at 3-, 5-, 7-, or7-day intervals. Binges ranged from 26.4 to 34.4 hours. Complications were proportional to the frequency of binging, (linear association p0.0007). The prematurity rate in group 1 was unexpectedly as high as that in group 2 (35.9% vs 34.3%). Acute problems (vaginal bleeding 21.8%, abruptio placentae 14.3%, stillbirths 20.5%) were most significant in group 1, while chronic problems (small-for-gestational-age infants 32.8%, systemic infections 31.3%, anemia 35.6%, and low maternal weight [100 pounds] 32.8%) were more significant in groups 2 and 3. Odds ratios show that prematurity, abruptio placentae, and vaginal bleeding were two to three times more likely to occur if test results for cocaine were positive at delivery. However, in group 1 the likelihood of abruptio placentae was unchanged whether toxicologic test results were positive (14.3%) or negative (14.0%), reflecting the role of cofactors in binging.Erratic use of cocaine-crack results in perinatal complications that are as severe as those occurring with daily binging but the patterns differ. Cofactors play a significant role in outcomes. |
| Databáze: | OpenAIRE |
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