Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

Autor: Julie A. Schmidt, Timothy J. Key, Sandar Tin Tin, Aurora Perez-Cornago, Anika Knuppel, Tammy Y.N. Tong, Carmen Piernas, Ruth C. Travis, Eleanor L. Watts, Rebecca K. Kelly, Cody Z. Watling
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Dietary Fiber
Male
medicine.medical_treatment
Critical Care and Intensive Care Medicine
SCFA
short chain fatty acids
Insulin-like growth factor
Eating
0302 clinical medicine
Medicine
Nutritional Physiological Phenomena
Food science
Insulin-Like Growth Factor I
Total protein
Biological Specimen Banks
Nutrition and Dietetics
Multivariable linear regression
HRT
hormone replacement therapy
Middle Aged
Protein intake
IGF-I
Original Article
Female
Macronutrients
Dietary Proteins
Alcohol
Alcohol consumption
Adult
Alcohol Drinking
030209 endocrinology & metabolism
BMI
Body mass index
IGFBP
insulin-like growth factor binding proteins
03 medical and health sciences
Humans
Aged
030109 nutrition & dietetics
Milk protein
business.industry
IGF-I
insulin-like growth factor-I
Protein
Biomarker
Nutrients
Somatomedin C
Confidence interval
United Kingdom
CI
confidence interval
Linear Models
Dairy Products
business
SD
standard deviation
Dietary protein intake
Zdroj: Clinical Nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
0261-5614
Popis: Background: Circulating insulin-like growth factor-I (IGF-I) is associated with the risk of several cancers. Dietary protein intake, particularly dairy protein, may increase circulating IGF-I; however, associations with different protein sources, other macronutrients, and fibre are inconclusive. Aim: To investigate the associations between intake of protein, macronutrients and their sources, fibre, and alcohol with serum IGF-I concentrations. Methods: A total of 11,815 participants from UK Biobank who completed ≥4 24-hour dietary assessments and had serum IGF-I concentrations measured at baseline were included. Multivariable linear regression was used to assess the cross-sectional associations of macronutrient and fibre intake with circulating IGF-I concentrations. Results: Circulating IGF-I concentrations were positively associated with intake of total protein (per 2.5% higher energy intake: 0.56 nmol/L, (95% confidence interval: 0.47, 0.66)), milk protein: 1.20 nmol/L (0.90, 1.51), and yogurt protein: 1.33 nmol/L (0.79, 1.86), but not with cheese protein: -0.07 nmol/L (-0.40, 0.25). IGF-I concentrations were also positively associated with intake of fibre (per 5 gram/day higher intake: 0.46 nmol/L (0.35, 0.57)) and starch from wholegrains (Q5 vs. Q1: 1.08 nmol/L (0.77, 1.39)), and inversely associated with alcohol consumption (>40 g/day vs Conclusions: These results show differing associations with IGF-I concentrations depending on the source of dairy protein, with positive associations with milk and yogurt protein but no association with cheese protein. The positive association of fibre and starch from wholegrains with IGF-I warrants further investigation.
Databáze: OpenAIRE
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