Pyroptotic cell-derived microparticle: An atherogenic factor in infectious diseases
| Autor: | Gui-qiong Zheng, Xiaoyong Lei, Shao-wei Sun, Wen-juan Tong, Qin-Hui Tuo, Duan-Fang Liao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death Cell Inflammation Communicable Diseases 03 medical and health sciences 0302 clinical medicine Cell-Derived Microparticles Pyroptosis medicine Humans Microparticle business.industry Macrophages Macrophage infiltration General Medicine Atherosclerosis Arterial vessel Chronic infection 030104 developmental biology medicine.anatomical_structure Immunology medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Medical Hypotheses. 146:110370 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2020.110370 |
| Popis: | Chronic infection is considered a risk factor for atherosclerosis. The link between infectious agents and atherosclerosis is manifested by the presence of infection-induced pyroptotic cells in atherosclerotic lesions. Pyroptosis is an inflammatory form of programmed cell death that occurs most frequently upon infection. However, inflammation is not the only cause by which pyroptosis involved in atherosclerosis. During pyroptosis, a large amount of microparticles are released from pyroptotic cells, which not only transfer inflammatory mediators to arterial vessel, but also mediate the interaction between a variety of cells, leading to endothelial injury, macrophage infiltration, vascular smooth muscle cell migration and proliferation, thereby accelerating atherosclerosis. Thus, we proposed hypothesis that pyroptotic cell-derived microparticle is an atherogenic factor in infectious diseases. |
| Databáze: | OpenAIRE |
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