What influences preneoplastic colorectal lesion recurrence?
| Autor: | Daniele Calistri, Claudia Rengucci, Giulia De Maio, Elisa Zama |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adenoma
medicine.medical_specialty recurrence Colon Colorectal cancer Review preneoplastic lesions Disease medicine.disease_cause Gastroenterology Lesion 03 medical and health sciences 0302 clinical medicine Internal medicine microbiota medicine Humans suppressor and serrated pathway business.industry Tumor Suppressor Proteins Rectum medicine.disease Gene Expression Regulation Neoplastic Oncology 030220 oncology & carcinogenesis Disease Progression 030211 gastroenterology & hepatology Neoplasm Recurrence Local medicine.symptom Colorectal Neoplasms business Carcinogenesis Precancerous Conditions |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Giulia De Maio 1 , Elisa Zama 1 , Claudia Rengucci 1 , Daniele Calistri 1 1 Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy Correspondence to: Daniele Calistri, email: daniele.calistri@irst.emr.it Keywords: recurrence, preneoplastic lesions, suppressor and serrated pathway, microbiota Received: August 02, 2016 Accepted: November 15, 2016 Published: November 25, 2016 ABSTRACT The hypothesis of the local recurrence of preneoplastic lesions was first put forward in the 1950s. Disease recurrence may result from an inherent imbalance in cell proliferation that promotes carcinogenesis in apparently normal mucosa. Our review sheds light on how early preneoplastic lesions could be used to diagnose relapsed preneoplastic and, developing neoplastic lesions. We focus in detail on the clinical-pathological and molecular features of adenoma subtypes and their role in relapsed adenoma and their development into colorectal carcinoma. Moreover, we include the data available on microbiota and its metabolites and their role in recurrence. We strongly believe that a significant improvement could be achieved in colorectal screening by introducing personalized endoscopic surveillance for polyp-bearing patients on the basis of the presence of molecular markers that are predictive of recurrence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|