Growth hormone does not affect albumin synthesis in the critically ill
| Autor: | Jan Wernerman, Peter J. Garlick, Lena Gamrin, Margaret A. McNurlan, Pia Essén, H. Barle |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Original Critical Illness Phenylalanine Serum albumin Critical Care and Intensive Care Medicine Growth hormone Affect (psychology) Gas Chromatography-Mass Spectrometry Liver Function Tests Internal medicine medicine Humans Prospective Studies Serum Albumin APACHE Aged Aged 80 and over Sweden biology medicine.diagnostic_test Critically ill business.industry Albumin Middle Aged Deuterium Intensive Care Units Hepatic Intensive care Liver Mass spectrometry Protein Endocrinology Liver metabolism Liver Growth Hormone biology.protein Female business Liver function tests Hormone |
| Zdroj: | Intensive Care Medicine |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s001340100914 |
| Popis: | Objective: To study the effect of growth hormone (GH) on albumin synthesis in critically ill patients. Design: Prospective randomized controlled study. Setting: Two intensive care units, university hospital and county hospital, respectively. Patients: Twenty-two critically ill patients in the intensive care unit. Interventions: Albumin synthesis was measured twice in each patient, with a 5-day interval. The patients in the control group (n=11) received standard intensive care unit (ICU) treatment between measurements, whereas those in the GH group (n=11) also received 0.3 U/kg daily of human recombinant GH. Measurements and results: Albumin synthesis was measured by labeling with L-[2H5]phenylalanine. In the control group, the fractional synthesis rate (FSR) of albumin was 16.3±4.1%/day (mean and SD) in the first measurement and 15.7±4.2%/day 5 days later (NS), whereas in the GH group the corresponding values were 17.0±4.7%/day and 16.7±5.5%/day (NS). The calculated absolute synthesis rates of albumin, based on FSR and intravascular albumin mass, also showed no effect of GH. Conclusion: Albumin synthesis rates were consistently higher in the two groups of critically ill patients than previously reported values in healthy subjects. However, GH treatment for 5 days neither stimulated nor inhibited albumin synthesis rates in these critically ill patients. |
| Databáze: | OpenAIRE |
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