PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

Autor: Galina Gabriely, Ana C. Anderson, Oleg Butovsky, Davide Mangani, Christian D Gauthier, Thais Garcias Moreira, Ana Maria Caetano Faria, David Correa Alves De Lima, Howard L. Weiner, Lydia Guo, Rafael M. Rezende, Brenda Naemi Nakagaki, Eduardo L C Lobo, Jeffrey A. Leibowitz, Laura M. Cox, Valerie Willocq, Mariana Assíria de Oliveira, Anya Song, Gopal Murugaiyan
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
ISSN: 2041-1723
Popis: The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are important in maintaining gut homeostasis. Here, we investigate DC transcriptome, phenotype and function in five anatomical locations of the gut lamina propria (LP) which constitute different antigenic environments. We show that DC from distinct gut LP compartments induce distinct T cell differentiation and cytokine secretion. We also find that PD-L1+ DC in the duodenal LP and XCR1+ DC in the colonic LP comprise distinct tolerogenic DC subsets that are crucial for gut homeostasis. Mice lacking PD-L1+ and XCR1+ DC have a proinflammatory gut milieu associated with an increase in Th1/Th17 cells and a decrease in Treg cells and have exacerbated disease in the models of 5-FU-induced mucositis and DSS-induced colitis. Our findings identify PD-L1+ and XCR1+ DC as region-specific physiologic regulators of intestinal homeostasis. Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut inflammation.
Databáze: OpenAIRE
Externí odkaz: