Prenatal stress impairs memory function in the early development of male-offspring associated with the gaba function
| Autor: | Hui Zhang, Fangjuan Li, Yingchun Shang, Haiyun Wang, Runwen Chen, Tao Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Offspring Experimental and Cognitive Psychology Biology Hippocampal formation Hippocampus 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Memory Pregnancy Internal medicine medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology gamma-Aminobutyric Acid Neuronal Plasticity 05 social sciences Long-term potentiation Rats Endocrinology Prenatal stress Prenatal Exposure Delayed Effects Synaptic plasticity Excitatory postsynaptic potential biology.protein Female Depotentiation 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Physiologybehavior. 228 |
| ISSN: | 1873-507X |
| Popis: | Prenatal stress (PS) induces cognitive deficits, abnormal behavior patterns and physical impairments in offspring, which disturbs the developmental process. GABA systems play a key role in the brain development. The developmental trajectories are less understood although PS increases the expression of GABAAR in young offspring. In the present study, we aimed to examine if the long-lasting effects on memory function and hippocampal synaptic plasticity induced by PS were associated with the GABA function throughout developmental process. Thus, a PS rat model was established by using restraint stress three 45-min periods per day from gestational day 15 until delivery. PS-exposed offspring exhibited the memory function deficits, LTP and depotentiation inhibitions in young and puberty offspring, but the disorder resolved at adult offspring. Meanwhile, the hippocampal spine density was decreased by PS in offspring. Additionally, we found that the balance of excitatory and inhibitory receptors was significantly disturbed after PS. The immunostaining of parvalbumin level was increased in the PS group. Overall, these all results suggest that the PS induces negative effects in memory and hippocampal synaptic plasticity in the early developmental stage, which could be an underlying mechanism of the disturbed GABA function. |
| Databáze: | OpenAIRE |
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