Surfactant replacement therapy: a new risk factor in developing retinopathy of prematurity?
| Autor: | D. Wittebol-Post, Hens A. A. Brouwers, Nicoline E. Schalij-Delfos, J. U. M. Termote, B. R. Hoogervorst, Bernard P. Cats |
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| Rok vydání: | 1994 |
| Předmět: |
Pediatrics
medicine.medical_specialty Respiratory Distress Syndrome Newborn Respiratory distress business.industry Infant Newborn Retinopathy of prematurity Pulmonary Surfactants Odds ratio medicine.disease Logistic regression eye diseases Confidence interval Surgery Risk Factors Pediatrics Perinatology and Child Health medicine Humans Retinopathy of Prematurity Risk factor business Complication human activities Retinopathy Retrospective Studies |
| Zdroj: | European journal of pediatrics. 153(2) |
| ISSN: | 0340-6199 |
| Popis: | We documented the prevalence of retinopathy of prematurity (ROP) in a group of 46 infants suffering from a moderate or severe respiratory distress syndrome and treated with surfactant replacement therapy (SRT) and 61 controls admitted in the year prior to the institution of SRT. Mortality in the treatment group was lower than in the control group (15.5% versus 23.8;P=0.29). The ROP prevalence in the treatment group was 47.8% and in the control group was 47.8% and in the control group 27.9%. To analyse the contribution of SRT alone to the prevalence of ROP, multivariate analysis using logistic regression technique was used. The odds ratio for SRT was 5.2 with a 95% confidence interval of 1.3–20.7,P=0.02. The prevalence of severe ROP in the surfactant treated group was not increased compared to the control group. From our data we conclude that SRT increases the risk of developing ROP but is not associated with more severe forms of ROP. |
| Databáze: | OpenAIRE |
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