Therapeutic management of hematological malignancies in elderly patients. Biological and clinical considerations. Part II: Non-Hodgkin lymphomas and Hodgkin's disease
| Autor: | Dennis Quaglino, E. Pasqualoni, N. Furia, G. Ciarrocchi, F. Recchia, G. Di Leonardo |
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| Rok vydání: | 1998 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Aging business.industry medicine.medical_treatment Incidence (epidemiology) Lymphoma Non-Hodgkin Follicular lymphoma Disease medicine.disease Hodgkin Disease Lymphoma B symptoms Internal medicine Immunology Antineoplastic Combined Chemotherapy Protocols Medicine Humans Geriatrics and Gerontology medicine.symptom business Pathological Multiple myeloma Aged |
| Zdroj: | Aging (Milan, Italy). 9(5) |
| ISSN: | 0394-9532 |
| Popis: | Increased knowledge of the nature and biology of lymphoid cells has provided more rational classification schemes, and has improved therapeutic strategies. However, non-Hodgkin lymphomas (NHL) as well as Hodgkin’s disease (HD) show a less favorable outcome in elderly compared to young patients. The poorer outcome in elderly patients with NHL is largely due to chemotherapy-related issues, although other age-related factors may contribute to determine a poor prognosis, such as the presence of more aggressive pathological subtypes and an increase in extranodal vs nodal presentations. Similarly, HD patients older than 50 years have higher rates of advanced disease, B symptoms, and histological types associated with poor prognosis at presentation. The poor prognosis in lymphoid malignancies also appears to be attributable to inadequate treatment. However, the inability to administer full therapy may be real, due to the high percentages of deaths caused by severe infections and intercurrent disease (cardiac, renal, lung) related to diminished organ function. The availability of growth factors may help to reduce the incidence of severe neutropenia and other related septic conditions. |
| Databáze: | OpenAIRE |
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