Intra-H-2 Recombination in H-2b/H-2t1 Heterozygotes in the Mouse I. Four Cases of Crossing Over between the S and D Regions
| Autor: | Howard C. Passmore, Kirk W. Beisel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Heterozygote
Immunology Mice Inbred Strains Biology Biochemistry law.invention Chromosomal crossover Mice Inbred strain law Genetics Animals Immunology and Allergy Crossing Over Genetic Typing Recombination Genetic Histocompatibility Testing Immune Sera Haplotype Chromosome General Medicine Histocompatibility Backcrossing Recombinant DNA Recombination |
| Zdroj: | Tissue Antigens. 9:121-130 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1977.tb01091.x |
| Popis: | An examination of 1009 backcross animals produced from H-2b/H-2t1 heterozygotes resulted in the detection of four cases of intra-H-2 recombination. Three of the recombinants received the K region from H-2b and the D region from the H-2t1 parenteral chromosome. The fourth recombinant received a K region from the H-2t1 parental chromosome and the D region from H-2b. Ss typing revealed that crossing over occurred between the S and D regions of the H-2 complex in all four cases. Three of the four recombinants were developed into inbred strains and assigned the haplotype designations H-2i8, H-2i9 and H-2at1. |
| Databáze: | OpenAIRE |
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