Novel approach to simulate sleep apnoea patients for evaluating positive pressure therapy devices
| Autor: | Dinesh Ramanan, Valentina Isetta, Ramon Farré, Holger Woehrle, Josep M. Montserrat, Alison Wimms, Daniel Navajas, Raquel Santano |
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| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Models
Anatomic Pulmonology Physiology Apnea lcsh:Medicine Dones Sleep physiology Algorismes Polysomnography Positive-Pressure Respiration 0302 clinical medicine Positive airway pressure Medicine and Health Sciences lcsh:Science Slow-wave sleep Sleep apnea syndromes Sleep Stages Multidisciplinary medicine.diagnostic_test Respiration Ingestion Physics Classical Mechanics Sleep apnea Equipment Design Síndromes d'apnea del son Sleep disorders Phenotype Neurology Breathing Anesthesia Physical Sciences Female medicine.symptom Rheology Algorithms Research Article Biotechnology Deglutició medicine.medical_specialty Sleep Apnea Posture 03 medical and health sciences Sleep Apnea Syndromes Physical medicine and rehabilitation Pressure medicine Humans Computer Simulation Women Wakefulness Trastorns del son business.industry Fisiologia del son lcsh:R Snoring Biology and Life Sciences Swallowing medicine.disease respiratory tract diseases Deglutition Obstructive sleep apnea Sleep deprivation 030228 respiratory system Sleep Deprivation lcsh:Q Medical Devices and Equipment Physiological Processes Sleep Sleep Disorders business 030217 neurology & neurosurgery High Pressure |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname PLoS ONE Dipòsit Digital de la UB Universidad de Barcelona PLoS ONE, Vol 11, Iss 3, p e0151530 (2016) |
| Popis: | Bench testing is a useful method to characterize the response of different automatic positive airway pressure (APAP) devices under well-controlled conditions. However, previous mod- els did not consider the diversity of obstructive sleep apnea (OSA) patients ' characteristics and phenotypes. The objective of this proof-of-concept study was to design a new bench test for realistically simulating an OSA patient ' s night, and to implement a one-night exam- ple of a typical female phenotype for comparing responses to several currently-available APAP devices. We developed a novel approach aimed at replicating a typical night of sleep which includes different disturbed breathing events, disease severities, sleep/wake phases, body postures and respiratory artefacts. The simulated female OSA patient example that we implemented included periods of wake, light sleep and deep sleep with positional changes and was connected to ten different APAP devices. Flow and pressure readings were recorded; each device was tested twice. The new approach for simulating female OSA patients effectively combined a wide variety of disturbed breathing patterns to mimic the response of a predefined patient type. There were marked differences in response between devices; only three were able to overcome flow limitation to normalize breathing, and only five devices were associated with a residual apnea-hypopnea index of < 5/h. In conclusion, bench tests can be designed to simulate specific patient characteristics, and typical stages of sleep, body position, and wake. Each APAP device behaved differently when exposed to this controlled model of a female OSA patient, and should lead to further understanding of OSA treatment. |
| Databáze: | OpenAIRE |
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