Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme
| Autor: | Palle Valentiner-Branth, Lotte Lambertsen, Zitta Barrella Harboe, Helle Bossen Konradsen, Karen A. Krogfelt, Thomas Benfield, M Howitz, Jens Jørgen Christensen, Peter Henrik Andersen |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Heptavalent Pneumococcal Conjugate Vaccine Adolescent Denmark Population complex mixtures Pneumococcal Infections Cohort Studies Pneumococcal Vaccines Young Adult stomatognathic system Case fatality rate medicine Humans education Child Aged Aged 80 and over education.field_of_study General Veterinary General Immunology and Microbiology business.industry Immunization Programs Incidence (epidemiology) Incidence Public Health Environmental and Occupational Health Age Factors Infant Newborn Infant Middle Aged medicine.disease Confidence interval Surgery Vaccination Infectious Diseases Child Preschool Molecular Medicine Female business Meningitis Cohort study |
| Zdroj: | Vaccine. 28(14) |
| ISSN: | 1873-2518 |
| Popis: | We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined approximately 10% (IRR 0.90; 95% CI [0.84-0.97]) in patients agedor=2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals. |
| Databáze: | OpenAIRE |
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