Alpha-1-microglobulin: Prognostic value in chronic kidney disease
| Autor: | Julian Valladares, Juan Lopez Gomez, I. Cerezo, Nicolás Roberto Robles, Roman Hernandez Gallego, Guadalupe Garcia Pino |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Percentile business.industry Proportional hazards model Urinary system Renal function Urine Middle Aged medicine.disease Prognosis Gastroenterology Excretion Internal medicine Alpha-Globulins medicine Humans Female Renal Insufficiency Chronic Alpha-1-microglobulin business Biomarkers Kidney disease Aged |
| Zdroj: | Medicina clinica. 157(8) |
| ISSN: | 1578-8989 |
| Popis: | Objectives α1-microglobulin (α1M) is a tubular protein used for detecting acute lesions of proximal tubules. This study evaluated the use of urine α1M excretion as a marker of chronic kidney disease progression and life survival. Design and methods In all 163 patients were recruited (90 men, mean age 61.6 ± 16.4 years). Urinary α1M was evaluated using an immunonephelometric assay. Patients were divided into two groups according to urinary α1M excretion (cut-off value, 32.85 mg/24 h). Results End stage renal disease-free survival was 94.2% at 5 years for patients with lower α1M. For patients in the highest percentile, renal function survival was 72.7% (P = .011). Life survival was 94.4% for patients with α1M in the lower percentiles. For patients in the upper percentile, live survival was 54.2% (P = .001). The Cox regression analysis showed an independent association of chronic kidney disease progression with high α1M excretion (P = .043). Conclusions α1M urinary excretion was associated with faster CKD progression and higher mortality. Further studies are needed to determine whether the association between α1M urinary excretion and excess mortality risk represents a causal link. |
| Databáze: | OpenAIRE |
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