Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount

Autor:	Xue-Yi Hu, Xiao-Ming Li, Bin-Gui Wang, Ling-Hong Meng
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Inorganic Chemistry marine endozoic fungus Penicillium steckii polyketide derivatives natural products structure elucidation biological activity Organic Chemistry General Medicine Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications
Zdroj:	International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6332
ISSN:	1422-0067
DOI:	10.3390/ijms23116332
Popis:	Four unusual steckwaic acids E–H (1–4), possessing a rarely described acrylic acid unit at C-4 (1–3) or a double bond between C-12 and C-13 (4) are reported for the first time, along with four new analogues (5–8) and two known congeners (9 and 10). They were purified from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral Acanthogorgiidae sp., which was collected from the Magellan Seamount at a depth of 1458 m. Their structures were determined by the interpretation of NMR and mass spectroscopic data. The relative and absolute configurations were determined by NOESY correlations, X-ray crystallographic analysis, and ECD calculations. All compounds were tested for their antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi.
Databáze:	OpenAIRE
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