Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration

Autor:	R. Ross MacLean, Tore Eid, Suprit Parida, Ralitza Gueorguieva, Elise E. DeVito, Mehmet Sofuoglu
Rok vydání:	2023
Předmět:	Pharmacology Psychiatry and Mental health Pharmacology (medical)
Zdroj:	Experimental and Clinical Psychopharmacology. 31:37-45
ISSN:	1936-2293 1064-1297
DOI:	10.1037/pha0000556
Popis:	A recent study demonstrated that during a single sampling period, 0.1 mg of intravenous (IV) nicotine (vs. placebo) was found to be the threshold for subjective and physiological drug effects. The present study is a secondary analysis evaluating whether the threshold for subjective and physiological effects is similar when the subject has repeated opportunities to choose blinded doses of nicotine versus placebo. We also examined whether cigarette craving, withdrawal, and rate of nicotine metabolism affected nicotine reinforcement, defined by a greater number of nicotine choices than placebo. Young adult (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980ac16edec4577b3839208ed6b4b2c7 https://doi.org/10.1037/pha0000556 Zobrazit plný text záznamu